PROFUSIO EXM is a compact add-on module that attaches easily to existing microscopes or inspection platforms. Its modular design allows users to enhance imaging performance without replacing their current equipment, reducing integration costs, installation complexity, and equipment downtime. EXM is powered by PROFUSIO’s physics-informed, learning-based computational optical imaging technology, which co-designs optical components and image reconstruction algorithms to extend the depth of field (DoF) by more than 15× while preserving high spatial resolution. This enables users to clearly visualize microscopic structures without repeated mechanical refocusing, improving imaging speed, robustness, and operational efficiency.