The ANDE Rapid Kinship System performs accurate DNA identification to enable family relationships to be identified in ~90 minutes. The System works outside the conventional lab and is operable by non-technical users, dramatically improving the utility of DNA analysis. Consisting of a ruggedized instrument, an AI-based Expert System, and a single-use consumable, major applications of the product include protecting children by determining familial relationships in immigration and disaster victim identification settings. The System protects privacy as the DNA fingerprint generated contains no information on the appearance, geographic ancestry, or health of the individual. The System operates using a microfluidic (small volume) Chip that is factory-preloaded with all reagents. The user simply inserts cheek swab samples into the chip and places the chip into the instrument. The system conducts hundreds of automated processing steps, and the AI-based software performs sophisticated kinship analyses to determine the kinship of the sample donors.